Abstract
Redirecting targeted proteins for degradation can overcome acquired drug resistance.
MeSH terms
-
Cell Line, Tumor
-
Drug Resistance, Neoplasm* / drug effects
-
Drug Resistance, Neoplasm* / genetics
-
Humans
-
Leukemia, Lymphocytic, Chronic, B-Cell* / drug therapy
-
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
-
Mutation
-
Protein Kinase Inhibitors* / pharmacology
-
Protein Kinase Inhibitors* / therapeutic use
-
Proteolysis* / drug effects
Substances
-
Protein Kinase Inhibitors