The Relationship of Spinal Anesthesia Dosing Based on Thecal Sac Area to Anesthetic Failure in Lumbar Surgery

Jainith Patel; Helen Karimi; Michelle Olmos; Liana Wiepert; Matthew Kanter; Nicholas S Hernandez; Jason M Frerich; Ron I Riesenburger; James Kryzanski

doi:10.1227/neu.0000000000002847

The Relationship of Spinal Anesthesia Dosing Based on Thecal Sac Area to Anesthetic Failure in Lumbar Surgery

Neurosurgery. 2024 Feb 1. doi: 10.1227/neu.0000000000002847. Online ahead of print.

Authors

Jainith Patel¹, Helen Karimi¹, Michelle Olmos¹, Liana Wiepert¹, Matthew Kanter¹, Nicholas S Hernandez², Jason M Frerich¹, Ron I Riesenburger¹, James Kryzanski¹

Affiliations

¹ Department of Neurosurgery, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.
² Department of Neurosurgery, University of California San Diego, La Jolla, California, USA.

PMID: 38299846
DOI: 10.1227/neu.0000000000002847

Abstract

Background and objectives: Greater thecal sac volumes are associated with an increased risk of spinal anesthesia (SA) failure. The thecal sac cross-sectional area accurately predicts thecal sac volume. The thecal sac area may be used to adjust the dose and prevent anesthetic failure. We aim to assess the rate of SA failure in a prospective cohort of lumbar surgery patients who receive an individualized dose of bupivacaine based on preoperative measurement of their thecal sac area.

Methods: A total of 80 patients prospectively received lumbar spine surgery under SA at a single academic center (2022-2023). Before surgery, the cross-sectional area of the thecal sac was measured at the planned level of SA injection using T2-weighted MRI. Patients with an area <175 mm2, equal to or between 175 and 225 mm2, and >225 mm2 received an SA injection of 15, 20, or 25 mg of 0.5% isobaric bupivacaine, respectively. Instances of anesthetic failure and adverse outcomes were noted. Incidence of SA failure was compared with a retrospectively obtained control cohort of 250 patients (2019-2022) who received the standard 15 mg of bupivacaine.

Results: No patients in the individualized dose cohort experienced failure of SA compared with 14 patients (5.6%) who experienced failure in the control cohort (P = .0259). The average thecal sac area was 187.49 mm2, and a total 28 patients received 15 mg of bupivacaine, 42 patients received 20 mg of bupivacaine, and 10 patients received 25 mg of bupivacaine. None of the patients experienced any adverse outcomes associated with SA. Patients in the individualized dose cohort and control cohort were comparable and had a similar distribution of lumbar procedures and comorbidities.

Conclusion: Adjusting the dose of SA according to thecal sac area significantly reduces the rate of SA failure in patients undergoing lumbar spine surgery.