Modulation of Angiotensin-II and Angiotensin 1-7 Levels Influences Cardiac Function in Myocardial Ischemia-reperfusion Injury

Prabhat Kumar Upadhyay; Navneet Thakur; Vishal Kumar Vishwakarma; Hridaya Shankar Chaurasiya; Tarique Mahmood Ansari

doi:10.2174/0125899775280160240122065607

Modulation of Angiotensin-II and Angiotensin 1-7 Levels Influences Cardiac Function in Myocardial Ischemia-reperfusion Injury

Curr Drug Res Rev. 2024 Jan 31. doi: 10.2174/0125899775280160240122065607. Online ahead of print.

Authors

Prabhat Kumar Upadhyay¹, Navneet Thakur², Vishal Kumar Vishwakarma², Hridaya Shankar Chaurasiya³, Tarique Mahmood Ansari⁴

Affiliations

¹ Institute of Pharmaceutical Research, GLA University, Mathura, 281406, Uttar Pradesh, India.
² Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
³ Faculty of Pharmacy, Jyotiraditya Institute of Pharmacy, Pratapgarh, India.
⁴ Department of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.

PMID: 38299413
DOI: 10.2174/0125899775280160240122065607

Abstract

The angiotensin-converting enzyme-2 (ACE-2) alters the pathophysiology of various fatal cardiovascular diseases, including ischemic heart disease, whereas angiotensin 1-7 (Ang 1-7) exerts a wide range of actions. The effects of ischemia-reperfusion (IR) injury include damage to myocardial tissue that initiates protease action, causing cardiac cell death. Angiotensin- II (Ang-II) contributes through the renin-angiotensin system (RAS) to the IR injury, whereas Ang 1-7 paradoxically exerts a protective effect through the same. Thus, the myocardial ischemic reperfusion injury (MIRI) may be altered by the RAS of the heart. This review paper focuses on ACE-2, angiotensin-converting enzyme (ACE), and Ang 1-7 regulation in the RAS of the heart in the pathophysiology of MIRI. The treatment in such conditions using ACE-2 activator, ACE inhibitor, and Ang-II antagonists may promote vascular functions as well as cardio- protection.

Keywords: ACE inhibitor; ACE-2 Activator; Angiotensin-II antagonist.; Heart; Rennin angiotensin system; Myocardial ischemia-reperfusion injury.