Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study

Payman Bagheri; Majid Nouri; Hesam Eskandarzadeh; Mohammad Darvishi

doi:10.2174/0127722708281623240116100806

Evaluation of Serum Levels of Vitamin D3 and IgE in Patients with Chronic and Allergic Sinusitis: A Cross-sectional Study

Recent Adv Inflamm Allergy Drug Discov. 2024 Jan 31. doi: 10.2174/0127722708281623240116100806. Online ahead of print.

Authors

Payman Bagheri¹, Majid Nouri², Hesam Eskandarzadeh³, Mohammad Darvishi⁴

Affiliations

¹ Aja University of Medical Sciences, Researcher and General Practitioner, Aja University of Medical Sciences, Tehran, Iran.
² Aja University of Medical Sciences, Infectious Research Center and Tropical Medicine, Aja University of Medical Sciences, Tehran, Iran.
³ Aja University of Medical Sciences, Department of Otolaryngology, Imam Reza Hospital, Aja University of Medical Sciences, Tehran, Iran.
⁴ Aja University of Medical Sciences, Infectious Diseases and Tropical Medicine Research Centre (IDTMRC), Department of Aerospace and Subaquatic Medicine, AJA University ofMedical Sciences, Tehran, Iran.

PMID: 38299409
DOI: 10.2174/0127722708281623240116100806

Abstract

Background: Chronic rhinosinusitis is known as a common problem with inflammatory and allergic causes. Several factors are associated with developing chronic rhinosinusitis, including immunoglobulin E (IgE) production and vitamin D deficiency.

Objective: In this study, we investigated the role of IgE and Vitamin D deficiency and differences between patients with chronic, allergic sinusitis and controls.

Methods: A total of 90 subjects were included in 3 groups (n=30) in this cross-sectional, correlational descriptive study. The subjects were divided into three groups, including control (healthy subjects), chronic sinusitis patients, and allergy patients. A checklist was used to collect the necessary data, including age, gender, and body mass index (BMI). To evaluate serum levels of vitamin D3 and IgE, ELISA kits were used.

Results: The mean vitamin D was 22 g/ml. Fifty-four participants (60%) out of all included people had insufficient vitamin D, 13% had a deficiency, and the high deficiency and insufficiency were in the group of allergic sinusitis. Our results indicated that gender (female) was significantly associated with vitamin D deficiency (p =0.01). Thirty-nine participants (43.3%) out of all studied subjects had high IgE, and the highest level of abnormality of IgE was in the allergic sinusitis group. Furthermore, it was found that gender and IgE were not significantly related. However, IgE was significantly associated with vitamin D deficiency in the allergic sinusitis group.

Conclusion: Our findings highlighted that most of the patients with chronic and allergic sinusitis had insufficient vitamin D. A possible association was also found between low vitamin D and IgE levels and the prevalence of allergic sinusitis. This study showed that patients with allergic sinusitis may be more vulnerable to lower serum levels of vitamin D. Therefore, vitamin D supplementation as an adjunctive therapy may be considered in these patients.

Keywords: IgE; Vitamin D3; allergic sinusitis.; chronic rhinosinusitis.