NcRNA: key and potential in hearing loss

Keyu Zhu; Ting Wang; Sicheng Li; Zeming Liu; Yuanyuan Zhan; Qi Zhang

doi:10.3389/fnins.2023.1333131

NcRNA: key and potential in hearing loss

Front Neurosci. 2024 Jan 17:17:1333131. doi: 10.3389/fnins.2023.1333131. eCollection 2023.

Authors

Keyu Zhu^#¹, Ting Wang^#², Sicheng Li^#³, Zeming Liu¹, Yuanyuan Zhan¹, Qi Zhang¹

Affiliations

¹ Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Medical Ultrasound, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
³ Department of Plastic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

^# Contributed equally.

Abstract

Hearing loss has an extremely high prevalence worldwide and brings incredible economic and social burdens. Mechanisms such as epigenetics are profoundly involved in the initiation and progression of hearing loss and potentially yield definite strategies for hearing loss treatment. Non-coding genes occupy 97% of the human genome, and their transcripts, non-coding RNAs (ncRNAs), are widely participated in regulating various physiological and pathological situations. NcRNAs, mainly including micro-RNAs (miRNAs), long-stranded non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are involved in the regulation of cell metabolism and cell death by modulating gene expression and protein-protein interactions, thus impacting the occurrence and prognosis of hearing loss. This review provides a detailed overview of ncRNAs, especially miRNAs and lncRNAs, in the pathogenesis of hearing loss. We also discuss the shortcomings and issues that need to be addressed in the study of hearing loss ncRNAs in the hope of providing viable therapeutic strategies for the precise treatment of hearing loss.

Keywords: age-related hearing loss; hearing loss; long-stranded non-coding RNA; micro-RNA; non-coding RNA; sensorineural hearing loss.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by financial support from the National Natural Science Foundation of China (grant number: 82202461) and Hubei Provincial Natural Science Foundation of China (2021CFB043).