Crosstalk between MicroRNAs and Oxidative Stress in Coeliac Disease

Filippo Pelizzaro; Romilda Cardin; Giulia Sarasini; Milena Minotto; Chiara Carlotto; Matteo Fassan; Michela Palo; Fabio Farinati; Fabiana Zingone

doi:10.1159/000536107

Crosstalk between MicroRNAs and Oxidative Stress in Coeliac Disease

Inflamm Intest Dis. 2024 Jan 24;9(1):11-21. doi: 10.1159/000536107. eCollection 2024 Jan-Dec.

Authors

Filippo Pelizzaro^{1

2}, Romilda Cardin¹, Giulia Sarasini¹, Milena Minotto¹, Chiara Carlotto¹, Matteo Fassan^{3

4}, Michela Palo¹, Fabio Farinati^{1

2}, Fabiana Zingone^{1

2}

Affiliations

¹ Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy.
² Gastroenterology Unit, Azienda Ospedale-Università di Padova, Padua, Italy.
³ Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, Italy.
⁴ Veneto Institute of Oncology IOV, IRCCS, Padua, Italy.

Abstract

MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in regulating gene expression. Many studies, mostly conducted on pediatric patients, suggested that oxidative stress and several miRNAs may play an important role in coeliac disease (CeD) pathogenesis. However, the interplay between oxidative stress and miRNA regulatory functions in CeD remains to be clarified. In this review, we aimed to perform a literature review on the role of miRNAs and oxidative stress in adult CeD patients and to analyze their potential interactions. In this direction, we also reported the preliminary results of a pilot study we recently performed.

Keywords: Coeliac disease; Diagnosis; Inflammation; MicroRNAs; Oxidative stress.

Publication types

Review

Grants and funding

Matteo Fassan is supported by grants from the Italian Health Ministry/Veneto Region Research Program NET-2016–02363853 and AIRC 5 per mille 2019 (ID. 22759 program). The pilot study was funded by BIRD funds from the University of Padova to Prof. Fabiana Zingone.