Coaxial electrospun Ag-NPs-loaded endograft membrane with long-term antibacterial function treating mycotic aortic aneurysm

Qingxi Hu; Zhenwei Huang; Haiguang Zhang; Pengcheng Ma; Rui Feng; Jiaxuan Feng

doi:10.1016/j.mtbio.2023.100940

Coaxial electrospun Ag-NPs-loaded endograft membrane with long-term antibacterial function treating mycotic aortic aneurysm

Mater Today Bio. 2024 Jan 2:25:100940. doi: 10.1016/j.mtbio.2023.100940. eCollection 2024 Apr.

Authors

Qingxi Hu^{1

2

3}, Zhenwei Huang¹, Haiguang Zhang^{1

2

3}, Pengcheng Ma⁴, Rui Feng⁵, Jiaxuan Feng⁶

Affiliations

¹ Rapid Manufacturing Engineering Center, School of Mechatronic Engineering and Automation, Shanghai University, Shanghai, 200444, China.
² Shanghai Key Laboratory of Intelligent Manufacturing and Robotics, Shanghai University, Shanghai, 200072, China.
³ National Demonstration Center for Experimental Engineering Training Education, Shanghai University, Shanghai, 200444, China.
⁴ Department of Vascular Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
⁵ Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China.
⁶ Vascular surgery department, Ruijin Hospital, affiliated to Medical school of Shanghai Jiaotong University, Shanghai, PR China.

Abstract

The use of endovascular stent-graft has become an important option in the treatment of aortic pathologies. However, the currently used endograft membranes have limited ability to prevent bacterial colonization. This makes them unsuitable for the treatment of mycotic aneurysms, as the infection is prone to progress after endograft implantation. Moreover, even in non-mycotic aortic pathologies, endograft infections can occur in the short or long term, especially for patients with diabetes mellitus or in immune insufficiency conditions. So, this study aimed to develop a kind of Ag-NPs-loaded endograft membrane by coaxial electrospinning technique, and a series of physical and chemical properties and biological properties of the Ag-NPs-loaded membrane were characterized. Animal experiments conducted in pigs confirmed that the Ag-NPs-loaded membrane was basically non-toxic, exhibited good biocompatibility, and effectively prevented bacterial growth in a mycotic aortic aneurysm model. In conclusion, the Ag-NPs-loaded membrane exhibited good biocompatibility, good anti-infection function and slow-release of Ag-NPs for long-term bacteriostasis. Thus, the Ag-NPs-loaded membrane might hold potential for preventing infection progression and treating mycotic aortic aneurysms in an endovascular way.

Keywords: Ag-NPs; Aortic aneurysm; Bacteriostasis; Coaxial electrospinning; Endograft.