Progress in mechanism-based diagnosis and treatment of tuberculosis comorbid with tumor

Front Immunol. 2024 Jan 17:15:1344821. doi: 10.3389/fimmu.2024.1344821. eCollection 2024.

Abstract

Tuberculosis (TB) and tumor, with similarities in immune response and pathogenesis, are diseases that are prone to produce autoimmune stress response to the host immune system. With a symbiotic relationship between the two, TB can facilitate the occurrence and development of tumors, while tumor causes TB reactivation. In this review, we systematically sorted out the incidence trends and influencing factors of TB and tumor, focusing on the potential pathogenesis of TB and tumor, to provide a pathway for the co-pathogenesis of TB comorbid with tumor (TCWT). Based on this, we summarized the latest progress in the diagnosis and treatment of TCWT, and provided ideas for further exploration of clinical trials and new drug development of TCWT.

Keywords: cancer; immunotherapy; pathogenesis; tuberculosis (TB); tuberculosis comorbid with tumor (TCWT); tumor.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Neoplasms* / complications
  • Neoplasms* / diagnosis
  • Neoplasms* / epidemiology
  • Tuberculosis* / diagnosis
  • Tuberculosis* / drug therapy
  • Tuberculosis* / epidemiology

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The authors acknowledge the support of 1.National Natural Science Foundation of China(Approval No.: 72264021);2.the Major Research Project of Philosophy and Social Sciences by the Ministry of Education of the People’s Republic of China (Approval No.: 21JZD039).