A compact, low-loss 2 × 1 angled-multi-mode-interference-based duplexer is proposed as an optical component for integrating several wavelengths with high coupling efficiency. The self-imaging principle in multimode waveguides is exploited to combine two target wavelengths, corresponding to distinctive absorption lines of important trace gases. The device performance has been numerically enhanced by engineering the geometrical parameters, offering trade-offs in coupling efficiency ratios. The proposed designs are used as versatile duplexers for detecting gas combinations such as ammonia-methane, ammonia-ethane, and ammonia-carbon dioxide, enabling customization for specific sensing applications. The duplexers designed are then fabricated and characterized, with a special focus on assessing the impact of the different target wavelengths on coupling efficiency.