Clinical and imaging predictors for hemorrhagic transformation of acute ischemic stroke after endovascular thrombectomy

Yongyao Kuang; Lingtao Zhang; Kunlin Ye; Zijie Jiang; Changzheng Shi; Liangping Luo

doi:10.1111/jon.13191

Clinical and imaging predictors for hemorrhagic transformation of acute ischemic stroke after endovascular thrombectomy

J Neuroimaging. 2024 Jan 31. doi: 10.1111/jon.13191. Online ahead of print.

Authors

Yongyao Kuang^{1

2}, Lingtao Zhang², Kunlin Ye², Zijie Jiang³, Changzheng Shi², Liangping Luo²

Affiliations

¹ Department of Radiology, Shunde Hospital of Southern Medical University, Foshan, China.
² Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China.
³ Medical Imaging Center, Shenzhen Hospital of Southern Medical University, Shenzhen, China.

PMID: 38296794
DOI: 10.1111/jon.13191

Abstract

Background and purpose: Hemorrhagic transformation (HT) is a common complication of endovascular thrombectomy (EVT) in patients with acute ischemic stroke (AIS). Our study aims to investigate the clinical and imaging predictors of HT and symptomatic intracranial hemorrhage (sICH) in patients who underwent EVT.

Methods: A retrospective analysis of 118 patients undergoing EVT for acute anterior circulation stroke was performed. Potential clinical and imaging predictors of all patients were collected and multivariate logistic regression was performed. The risk prediction system was constructed according to the multivariate logistic regression results.

Results: The incidence of HT and sICH after EVT were 46.6% and 15.3%, respectively. The multivariate logistic regression results showed that Alberta Stroke Program Early CT Score (ASPECTS) (p = .001, odds ratio [OR] = 0.367, 95% [confidence interval] CI, 0.201-0.670), collateral status (p<.001, OR = 0.117, 95% CI, 0.042-0.325), relative cerebral blood flow (CBF) ratio (p = .025, OR = 0.943, 95% CI, 0.895-0.993), and blood glucose on admission (p = .012, OR = 1.258, 95% CI, 1.053-1.504) were associated with HT. While for sICH, collateral circulation (p = .007, OR = 0.148, 95% CI, 0.037-0.589), ASPECTS (p = .033, OR = 0.510, 95% CI, 0.274-0.946), and blood glucose (p = .005, OR = 1.304, 95% CI, 1.082-1.573) were independent factors. The predictive model for HT after EVT was established, and the sensitivity and specificity of it were 90.9% and 79.4%, respectively, with the area under the curve of 90.0% (84.5%-95.4%).

Conclusion: Collateral status, ASPECTS, relative CBF ratio, and blood glucose on admission were predictors for HT in AIS patients, while collateral status, ASPECTS, and blood glucose on admission were also predictors for sICH. In addition, the established predictive model showed good diagnostic value for prediction of HT after EVT.

Keywords: endovascular thrombectomy; hemorrhagic transformation; imaging predictors; stroke.

Abstract

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