Harmonizing the forensic nomenclature for STR loci D6S474 and DYS612

Forensic Sci Int Genet. 2024 May:70:103012. doi: 10.1016/j.fsigen.2024.103012. Epub 2024 Jan 21.

Abstract

The autosomal STR D6S474 and the Y-chromosomal STR DYS612 have been reported in multiple ways in the forensic literature, with differences in both the bracketed repeat structures and counting of numerical length-based capillary electrophoresis (CE) alleles. These issues often come to light when STR loci are introduced in commercial assays and results compared with historical publications of allele frequency data, or multiple assays are characterized with reference materials. We review the forensic literature and other relevant information, and provide suggestions for the future treatment of each STR.

Keywords: Repeat unit; STR bracketing; STR motif.

Publication types

  • Review

MeSH terms

  • Alleles
  • DNA Fingerprinting* / methods
  • Gene Frequency
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Microsatellite Repeats*