Nanocarrier-based localized and effective treatment of renal disorders: currently employed targeting strategies

Nanomedicine (Lond). 2024 Feb;19(4):345-361. doi: 10.2217/nnm-2023-0251. Epub 2024 Jan 31.

Abstract

Renal disorders pose a global health threat, with targeted drug-delivery systems emerging as a promising strategy to enhance therapy safety and efficacy. Recent efforts have harnessed targeted nanomaterials for kidney disease treatment. While some systems remain in the early stages, they show immense potential in delivering cargo to specific sites. Through animal model experimentations, it has been demonstrated to reduce systemic side effects and enhance treatment effectiveness. This review presents current strategies for kidney disorder treatment, emphasizing site-specific targeting critical to renal disease pathophysiology. Recent advancements in nano-drug delivery systems for kidney targeting are explored. Finally, toxicological aspects and prospects of the most promising kidney-targeting delivery systems are discussed in this review article.

Keywords: active targeting; nanocarriers; renal disorders; targeted renal nanotherapy; toxicological perspectives.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Carriers / therapeutic use
  • Drug Delivery Systems
  • Kidney
  • Kidney Diseases* / drug therapy
  • Nanoparticles*
  • Nanostructures*
  • Treatment Outcome

Substances

  • Drug Carriers