A literature review of bioactive substances for the treatment of periodontitis: In vitro, in vivo and clinical studies

Tae-Hee Kim; Seong-Yeong Heo; Pathum Chandika; Young-Mog Kim; Hyun-Woo Kim; Hyun Wook Kang; Jae-Young Je; Zhong-Ji Qian; Namwon Kim; Won-Kyo Jung

doi:10.1016/j.heliyon.2024.e24216

A literature review of bioactive substances for the treatment of periodontitis: In vitro, in vivo and clinical studies

Heliyon. 2024 Jan 11;10(2):e24216. doi: 10.1016/j.heliyon.2024.e24216. eCollection 2024 Jan 30.

Authors

Tae-Hee Kim^{1

2}, Seong-Yeong Heo³, Pathum Chandika^{1

2}, Young-Mog Kim^{1

2

4}, Hyun-Woo Kim^{1

2

5}, Hyun Wook Kang^{1

2

6}, Jae-Young Je^{1

7}, Zhong-Ji Qian^{8

9

10}, Namwon Kim^{11

12}, Won-Kyo Jung^{1

2

6}

Affiliations

¹ Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan, 48513, Republic of Korea.
² Marine Integrated Biomedical Technology Center, The National Key Research Institutes in Universities, Pukyong National University, Busan, 48513, Republic of Korea.
³ Jeju Marine Research Center, Korea Institute of Ocean Science & Technology (KIOST), Jeju, 63349, Republic of Korea.
⁴ Department of Food Science and Technology, Pukyong National University, Busan, 48513, Republic of Korea.
⁵ Department of Marine Biology, Pukyong National University, Busan, 48513, Republic of Korea.
⁶ Major of Biomedical Engineering, Division of Smart Healthcare, College of Information Technology and Convergence and New-senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan, 48513, Republic of Korea.
⁷ Major of Human Bioconvergence, School of Smart Healthcare, Pukyong National University, Busan, 48513, Republic of Korea.
⁸ College of Food Science and Technology, School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang, 524088, China.
⁹ Shenzhen Institute of Guangdong Ocean University, Guangdong Ocean University, Shenzhen, 518108, China.
¹⁰ Southern Marine Science and Engineering Guangdong Laboratory, Zhanjiang, 524025, China.
¹¹ Ingram School of Engineering, Texas State University, San Marcos, TX, 78666, USA.
¹² Materials Science, Engineering, and Commercialization (MSEC), Texas State University, San Marcos, TX, 78666, USA.

Abstract

Periodontitis is a common chronic inflammatory disease of the supporting tissues of the tooth that involves a complex interaction of microorganisms and various cell lines around the infected site. To prevent and treat this disease, several options are available, such as scaling, root planning, antibiotic treatment, and dental surgeries, depending on the stage of the disease. However, these treatments can have various side effects, including additional inflammatory responses, chronic wounds, and the need for secondary surgery. Consequently, numerous studies have focused on developing new therapeutic agents for more effective periodontitis treatment. This review explores the latest trends in bioactive substances with therapeutic effects for periodontitis using various search engines. Therefore, this study aimed to suggest effective directions for therapeutic approaches. Additionally, we provide a summary of the current applications and underlying mechanisms of bioactive substances, which can serve as a reference for the development of periodontitis treatments.

Keywords: Bioactive substances; Human gingival fibroblasts; Periodontitis.

Publication types

Review