Phytochemical and pharmacological profile of genus shorea: A review of the recent literature

Abdullahi Musa; Nanik Siti Aminah; Alfinda Novi Kristanti; Imam Fathoni; Rizka Tazky Amalia; Tin Myo Thant; P Rajasulochana; Yoshiaki Takaya

doi:10.1016/j.heliyon.2023.e23649

Phytochemical and pharmacological profile of genus shorea: A review of the recent literature

Heliyon. 2023 Dec 29;10(2):e23649. doi: 10.1016/j.heliyon.2023.e23649. eCollection 2024 Jan 30.

Authors

Abdullahi Musa¹, Nanik Siti Aminah^{1

2}, Alfinda Novi Kristanti^{1

2}, Imam Fathoni¹, Rizka Tazky Amalia¹, Tin Myo Thant³, P Rajasulochana⁴, Yoshiaki Takaya⁵

Affiliations

¹ Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
² Biotechnology of Tropical Medicinal Plants Research Group, Universitas Airlangga, Surabaya, Indonesia.
³ Department of Chemistry, Mandalay University, Mandalay, Myanmar.
⁴ Department of Microbiology, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Saveetha Nagar, Thandalam, Kanchipuram, Tamil Nadu 602105, India.
⁵ Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya, 468-8503 Japan.

Abstract

In tropical Southeast Asia, Shorea is the most economically important tree and the largest genus in the Dipterocarpaceae family. It comprises about 150-200 species, of which majority are distributed in Malaysia, with others found in Sumatra and Borneo (Kalimantan) in Indonesia. Research on the chemical constituents of Shorea plants has been ongoing for many years. To date, a total of 113 different compounds, including 83 stilbenes and their resveratrol oligomers, 18 triterpenes/terpenoids, 7 coumarins 3 flavonoids and 2 steroids have been isolated and successfully elucidated from 26 different species of this genus. The diversity of the stilbene resveratrol oligomers in the Shorea genus is primarily due to the difference in the amount of resveratrol constituent units, which include dimers, trimers and tetramers. In addition to the species' traditional usage in the treatment of illnesses, such as diarrhea, toothaches, skin diseases, ear troubles and wounds, the extracts and secondary metabolite compounds isolated from various parts of the plant species are known to have a very potent antioxidant, antimicrobial, anticancer, anti-diabetic, anti-obesity, antiulcer, hepatoprotective and nephroprotective activities. This review aims to summarize the most recent research made from 1999 to date on the secondary metabolite compounds isolated from different species of genus Shorea, as well as the bioactivity (in vitro and in vivo) of the crude extracts and the isolated secondary metabolite compounds.

Keywords: Coumarins; Dipterocarpaceae; Oligostibene; Shorea; Triterpenoids.

Publication types

Review