Comparative label-free proteomics of the neonatal meningitis-causing Escherichia coli K1 IHE3034 and RS218 morphotypes

Nikola Zlatkov; Wilma Gunnari; Ulrike Resch

doi:10.1128/mra.00960-23

Comparative label-free proteomics of the neonatal meningitis-causing Escherichia coli K1 IHE3034 and RS218 morphotypes

Microbiol Resour Announc. 2024 Feb 15;13(2):e0096023. doi: 10.1128/mra.00960-23. Epub 2024 Jan 30.

Authors

Nikola Zlatkov¹, Wilma Gunnari¹, Ulrike Resch²

Affiliations

¹ Department of Molecular Biology, Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
² Department of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Abstract

The proteome of two newborn meningitis Escherichia coli K1 (NMEC) morphotypes was examined via a label-free proteomics approach. Besides shared NMEC virulence factors, the two strains have different evolutionary strategies-strain IHE3034 tends to perform anaerobic respiration continuously, while strain RS218 maintains its filamentous morphotype due to active SOS response.

Keywords: ExPEC; NMEC; newborn meningitis; proteomics.

Abstract

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