Exploring the untapped pharmacological potential of imidazopyridazines

RSC Adv. 2024 Jan 29;14(6):3972-3984. doi: 10.1039/d3ra07280k. eCollection 2024 Jan 23.

Abstract

Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and antimalarial agents. In addition to this, they have also been investigated for their anticonvulsant, antiallergic, antihistamine, antiviral, and antitubercular properties. Herein, we review the background and development of different imidazopyridazines as potential pharmacological agents. Moreover, the scope of this relatively less charted heterocyclic scaffold is also highlighted.

Publication types

  • Review