The crosstalk between subjective fibromyalgia, mental health symptoms and the use of over-the-counter analgesics in female Syrian refugees: a cross-sectional web-based study

Rheumatol Int. 2024 Apr;44(4):715-723. doi: 10.1007/s00296-023-05521-0. Epub 2024 Jan 29.

Abstract

Suboptimal fibromyalgia management with over-the-counter analgesics leads to deteriorated outcomes for pain and mental health symptoms especially in low-income countries hosting refugees. To examine the association between the over-the-counter analgesics and the severity of fibromyalgia, depression, anxiety and PTSD symptoms in a cohort of Syrian refugees. This is a cross-sectional study. Fibromyalgia was assessed using the patient self-report survey for the assessment of fibromyalgia. Depression was measured using the Patient Health Questionnaire-9, insomnia severity was measured using the insomnia severity index (ISI-A), and PTSD was assessed using the Davidson trauma scale (DTS)-DSM-IV. Data were analyzed from 291. Among them, 221 (75.9%) reported using acetaminophen, 79 (27.1%) reported using non-steroidal anti-inflammatory drugs (NSAIDs), and 56 (19.2%) reported receiving a prescription for centrally acting medications (CAMs). Fibromyalgia screening was significantly associated with using NSAIDs (OR 3.03, 95% CI 1.58-5.80, p = 0.001). Severe depression was significantly associated with using NSAIDs (OR 2.07, 95% CI 2.18-3.81, p = 0.02) and CAMs (OR 2.74, 95% CI 1.30-5.76, p = 0.008). Severe insomnia was significantly associated with the use of CAMs (OR 3.90, 95% CI 2.04-5.61, p < 0.001). PTSD symptoms were associated with the use of CAMs (β = 8.99, p = 0.001) and NSAIDs (β = 10.39, p < 0.001). Improper analgesics are associated with poor fibromyalgia and mental health outcomes, prompt awareness efforts are required to address this challenge for the refugees and health care providers.

Keywords: Female; Fibromyalgia; Mental health; Refugees; Surveys and questionnaires; Syria.

MeSH terms

  • Analgesics / adverse effects
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cross-Sectional Studies
  • Depression / drug therapy
  • Female
  • Fibromyalgia* / diagnosis
  • Fibromyalgia* / drug therapy
  • Humans
  • Internet
  • Mental Health
  • Refugees*
  • Sleep Initiation and Maintenance Disorders*
  • Stress Disorders, Post-Traumatic* / drug therapy
  • Syria

Substances

  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal