Recent Progress in the Application of Exosome Analysis in Ovarian Cancer Management

Vahideh Keyvani; Zari Naderi Ghale-Noie; Samaneh Mollazadeh; Reihaneh Alsadat Mahmoudian; Elnaz Ghorbani; Hamid Naderi; Majid Khazaei; Seyed Mahdi Hassanian; Gordon A Ferns; Amir Avan; Kazem Anvari

doi:10.2174/0115680096281906231213055422

Recent Progress in the Application of Exosome Analysis in Ovarian Cancer Management

Curr Cancer Drug Targets. 2024 Jan 25. doi: 10.2174/0115680096281906231213055422. Online ahead of print.

Authors

Vahideh Keyvani^{1

2

3}, Zari Naderi Ghale-Noie¹, Samaneh Mollazadeh⁴, Reihaneh Alsadat Mahmoudian^{3

5

6}, Elnaz Ghorbani³, Hamid Naderi³, Majid Khazaei³, Seyed Mahdi Hassanian³, Gordon A Ferns⁷, Amir Avan^{3

8

9}, Kazem Anvari⁶

Affiliations

¹ Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.
⁵ Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁶ Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁷ Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, SussexBN1 9PH, UK.
⁸ College of Medicine, University of Warith Al-Anbiyaa, Karbala, Iraq.
⁹ Faculty of Health, School of Biomedical Sciences, Queensland University of Technology (QUT), Brisbane 4059, Australia.

PMID: 38284712
DOI: 10.2174/0115680096281906231213055422

Abstract

Exosomes are very small (nano-sized) vesicles participating in tumor development by involvement in intercellular communication mediated by transferring biocomponents. Exosomes appear to play vital roles in various cancer development, such as ovarian cancer, a common malignancy in women. Several hallmarks of ovarian cancer are reported to be affected by the exosome-- mediated cellular cross-talk, including modulating peritoneal dissemination and chemoresistance. Since the expression of some biomolecules, such as miRNAs and mRNA, is changed in ovarian cancer, these exo-biomolecules can be applied as prognostic, diagnostic, and therapeutic biomarkers. Also, the selective loading of specific chemotherapeutic agents into exosomes highlights these biocarries as potential delivery devices. Exosomes could be artificially provided and engineered to better target the site of interest in ovarian cancer. In the present review, we summarize the notable achievement of exosome application in ovarian cancer management to gain applicable transitional insight against this cancer.

Keywords: Ovarian cancer; bioactive molecules; biomarkers; delivery vehicles.; exosomes.