Risk of serious intracranial pathology in children presenting with acute acquired comitant esotropia

Elie Côté; Y Arun Reginald; Michael J Wan

doi:10.1016/j.jcjo.2024.01.002

Risk of serious intracranial pathology in children presenting with acute acquired comitant esotropia

Can J Ophthalmol. 2024 Jan 25:S0008-4182(24)00001-2. doi: 10.1016/j.jcjo.2024.01.002. Online ahead of print.

Authors

Elie Côté¹, Y Arun Reginald¹, Michael J Wan²

Affiliations

¹ Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON; Department of Ophthalmology and Vision Sciences, Hospital for Sick Children, Toronto, ON.
² Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON; Department of Ophthalmology and Vision Sciences, Hospital for Sick Children, Toronto, ON.. Electronic address: michael.wan@sickkids.ca.

PMID: 38281727
DOI: 10.1016/j.jcjo.2024.01.002

Abstract

Objective: Acute acquired comitant esotropia (AACE) is defined as a sudden-onset constant nonaccommodative esodeviation. The purpose of this study was to determine the risk of serious intracranial pathology in children presenting with AACE.

Design: Retrospective observational cohort study.

Setting: Tertiary care pediatric hospital.

Methods: The study included consecutive children who met the diagnostic criteria for AACE and had neuroimaging at a tertiary care pediatric hospital between 2000 and 2020. Patients were identified by searching the radiology database for all children who underwent neuroimaging for esotropia. The primary outcome measure was the proportion of patients with serious intracranial pathology. Secondary outcomes included risk factors for finding likely causative intracranial pathology and the proportion of patients with incidental findings.

Results: A total of 107 patients met the inclusion criteria. Most of the patients (75.7%) had normal neuroimaging. The next most common result was an incidental finding unrelated to the esotropia (18.7%). Five patients (4.7%) had findings with uncertain contribution to esotropia, including 3 cases of type I Chiari malformation. A serious intracranial pathology was found in 1 patient (0.9%) who had a cerebellar medulloblastoma.

Conclusion: In this large series of pediatric patients with AACE who underwent neuroimaging, there was a small but nontrivial risk of serious intracranial pathology. In these patients, it is advisable either to obtain neuroimaging or to monitor closely for the development of concerning signs or symptoms.