The potential role of Hippo pathway regulates cellular metabolism via signaling crosstalk in disease-induced macrophage polarization

Yina An; Shuyu Tan; Jingjing Yang; Ting Gao; Yanjun Dong

doi:10.3389/fimmu.2023.1344697

The potential role of Hippo pathway regulates cellular metabolism via signaling crosstalk in disease-induced macrophage polarization

Front Immunol. 2024 Jan 11:14:1344697. doi: 10.3389/fimmu.2023.1344697. eCollection 2023.

Authors

Yina An¹, Shuyu Tan¹, Jingjing Yang¹, Ting Gao², Yanjun Dong¹

Affiliations

¹ National Key Laboratory of Veterinary Public Health Security, College of Veterinary Medicine, China Agricultural University, Beijing, China.
² College of Veterinary Medicine, China Agricultural University, Beijing, China.

Abstract

Macrophages polarized into distinct phenotypes play vital roles in inflammatory diseases by clearing pathogens, promoting tissue repair, and maintaining homeostasis. Metabolism serves as a fundamental driver in regulating macrophage polarization, and understanding the interplay between macrophage metabolism and polarization is crucial for unraveling the mechanisms underlying inflammatory diseases. The intricate network of cellular signaling pathway plays a pivotal role in modulating macrophage metabolism, and growing evidence indicates that the Hippo pathway emerges as a central player in network of cellular metabolism signaling. This review aims to explore the impact of macrophage metabolism on polarization and summarize the cell signaling pathways that regulate macrophage metabolism in diseases. Specifically, we highlight the pivotal role of the Hippo pathway as a key regulator of cellular metabolism and reveal its potential relationship with metabolism in macrophage polarization.

Keywords: Hippo; inflammatory diseases; macrophage polarization; metabolism; regulatory network.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Hippo Signaling Pathway*
Macrophages / metabolism
Phenotype
Signal Transduction*

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Key Research and Development Program of China No. 2022YFD1800400.