Streptomyces albireticuli lung infection managed as a pulmonary air cyst: a case report and literature review

Front Cell Infect Microbiol. 2024 Jan 11:13:1296491. doi: 10.3389/fcimb.2023.1296491. eCollection 2023.

Abstract

Streptomyces, the largest genus in the Streptomycetaceae family and a prolific producer of antibacterial drugs, is a saprophytic soil organism that rarely causes invasive infections. Here we report a case of necrotic pneumonia caused by Streptomyces albireticuli in a 75-year-old man who presented with progressive chest tightness and dyspnea. Streptomyces albireticuli was isolated from his bronchoalveolar lavage fluid and identified through whole-genome sequencing (WGS) and phylogenetic analysis. The patient responded satisfactorily to clarithromycin therapy. The findings of this study may enhance our vigilance in identifying visceral infections caused by Streptomyces.

Keywords: Streptomyces albireticuli; case report; gene sequencing; lung infection; pulmonary air cyst.

Publication types

  • Review
  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cysts*
  • Humans
  • Lung
  • Lung Diseases*
  • Male
  • Phylogeny
  • Pneumonia*
  • Streptomyces* / genetics

Supplementary concepts

  • Streptomyces albireticuli

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Sichuan Provincial Cadre Health Research Project (2022-1303) and Military Medical Research Project of the General Hospital of the Western Theater Command Funding (2019LH05).