Association between ambient particulate matter levels and hypertension: results from the Korean Genome and Epidemiology Study

Sewhan Na; Jong-Tae Park; Seungbeom Kim; Jinwoo Han; Saemi Jung; Kyeongmin Kwak

doi:10.35371/aoem.2023.35.e51

Association between ambient particulate matter levels and hypertension: results from the Korean Genome and Epidemiology Study

Ann Occup Environ Med. 2023 Dec 4:35:e51. doi: 10.35371/aoem.2023.35.e51. eCollection 2023.

Authors

Sewhan Na^{1

2}, Jong-Tae Park^{1

3

4}, Seungbeom Kim¹, Jinwoo Han¹, Saemi Jung⁵, Kyeongmin Kwak^{1

3

4}

Affiliations

¹ Department of Occupational and Environmental Medicine, Korea University Ansan Hospital, Ansan, Korea.
² Department of Environmental Health Sciences, Seoul National University Graduate School of Public Health, Seoul, Korea.
³ Department of Occupational and Environmental Medicine, Korea University College of Medicine, Seoul, Korea.
⁴ Department of Environmental and Occupational Health, Korea University Graduate School of Public Health, Seoul, Korea.
⁵ Department of Occupational and Environmental Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.

Abstract

Background: Recently, there has been increasing worldwide concern about outdoor air pollution, especially particulate matter (PM), which has been extensively researched for its harmful effects on the respiratory system. However, sufficient research on its effects on cardiovascular diseases, such as hypertension, remains lacking. In this study, we examine the associations between PM levels and hypertension and hypothesize that higher PM concentrations are associated with elevated blood pressure.

Methods: A total of 133,935 adults aged ≥ 40 years who participated in the Korean Genome and Epidemiology Study were analyzed. Multiple linear regression analyses were conducted to investigate the short- (1-14 days), medium- (1 and 3 months), and long-term (1 and 2 years) impacts of PM on blood pressure. Logistic regression analyses were conducted to evaluate the medium- and long-term effects of PM on blood pressure elevation after adjusting for sex, age, body mass index, health-related lifestyle behaviors, and geographic areas.

Results: Using multiple linear regression analyses, both crude and adjusted models generated positive estimates, indicating an association with increased blood pressure, with all results being statistically significant, with the exception of PM levels over the long-term period (1 and 2 years) in non-hypertensive participants. In the logistic regression analyses on non-hypertensive participants, moderate PM₁₀ (particulate matter with diameters < 10 μm) and PM_2.5 (particulate matter with diameters < 2.5 μm) levels over the long-term period and all high PM₁₀ and PM_2.5 levels were statistically significant after adjusting for various covariates. Notably, high PM_2.5 levels of the 1 year exhibited the highest odds ratio of 1.23 (95% confidence interval: 1.19-1.28) after adjustment.

Conclusions: These findings suggest that both short- and long-term exposure to PM is associated with blood pressure elevation.

Keywords: Blood pressure; Hypertension; Outdoor air pollution; Particulate matter.