Regulation of fatty acid synthase on tumor and progress in the development of related therapies

Rilan Bai; Jiuwei Cui

doi:10.1097/CM9.0000000000002880

Regulation of fatty acid synthase on tumor and progress in the development of related therapies

Chin Med J (Engl). 2024 Jan 26. doi: 10.1097/CM9.0000000000002880. Online ahead of print.

Authors

Rilan Bai¹, Jiuwei Cui

Affiliation

¹ Cancer Center, the First Hospital of Jilin University, Changchun, Jilin 130021, China.

PMID: 38273440
DOI: 10.1097/CM9.0000000000002880

Abstract

Fatty acid synthase (FASN) is an essential molecule in lipid metabolic pathways, which are crucial for cancer-related studies. Recent studies have focused on a comprehensive understanding of the novel and important regulatory effects of FASN on malignant biological behavior and immune-cell infiltration, which are closely related to tumor occurrence and development, immune escape, and immune response. FASN-targeting antitumor treatment strategies are being developed. Therefore, in this review, we focused on the effects of FASN on tumor and immune-cell infiltration and reviewed the progress of related anti-tumor therapy development.