Genome-wide CRISPR/Cas9 screen identifies regulators of BCMA expression on multiple myeloma cells

Ram Ajore; Jenny Mattsson; Maroulio Pertesi; Ludvig Ekdahl; Zain Ali; Markus Hansson; Björn Nilsson

doi:10.1038/s41408-024-00986-z

Genome-wide CRISPR/Cas9 screen identifies regulators of BCMA expression on multiple myeloma cells

Blood Cancer J. 2024 Jan 25;14(1):21. doi: 10.1038/s41408-024-00986-z.

Authors

Ram Ajore^{1

2}, Jenny Mattsson^{1

2

3}, Maroulio Pertesi^{1

2}, Ludvig Ekdahl^{1

2}, Zain Ali^{1

2}, Markus Hansson^{1

4}, Björn Nilsson^{5

6

7}

Affiliations

¹ Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, 221 84, Lund, Sweden.
² Lund Stem Cell Center, Lund University, 221 84, Lund, Sweden.
³ BioInvent International AB, Ideongatan 1, 223 70, Lund, Sweden.
⁴ Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, Göteborg University, 41346, Göteborg, Sweden.
⁵ Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University, 221 84, Lund, Sweden. bjorn.nilsson@med.lu.se.
⁶ Lund Stem Cell Center, Lund University, 221 84, Lund, Sweden. bjorn.nilsson@med.lu.se.
⁷ Broad Institute, Cambridge, MA, 02142, USA. bjorn.nilsson@med.lu.se.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

B-Cell Maturation Antigen
CRISPR-Cas Systems
Cell Line, Tumor
Humans
Multiple Myeloma* / genetics
Multiple Myeloma* / metabolism

Substances

B-Cell Maturation Antigen