Human Xenograft Model

Abstract

Human-SCID grafting is a commonly used technique for the long-term investigation of rheumatoid arthritis (RA) explants. To establish a chimeric immunological system in NOD/SCID mice, RA patient-derived pannus tissue from the synovial membrane, articular cartilage, and bone can be transplanted subcutaneously. Same patient-derived peripheral mononuclear cell chimerism can be successfully achieved by intraperitoneal engraftment. This xenograft model is able to be used for the initial screening of human target-specified biologics.

Keywords: Articular tissue; NOD/SCID mouse; Peripheral mononuclear cell; Synovial invasion; Xenograft rheumatoid arthritis model.