Synchronizing beta cells in the pancreas

Bradford E Peercy; David J Hodson

doi:10.7554/eLife.95103

Synchronizing beta cells in the pancreas

Elife. 2024 Jan 25:13:e95103. doi: 10.7554/eLife.95103.

Authors

Bradford E Peercy¹, David J Hodson²

Affiliations

¹ Department of Mathematics and Statistics, University of Maryland Baltimore County (UMBC), Baltimore, United States.
² Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), NIHR Oxford Biomedical Research Centre, Churchill Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

Abstract

The secretion of insulin from the pancreas relies on both gap junctions and subpopulations of beta cells with specific intrinsic properties.

Keywords: beta-cell; beta-cell oscillations; computational biology; coordinated oscillations; heterogeneity; insulin release; islet; mouse; network theory; physics of living systems; systems biology.

Publication types

Editorial

MeSH terms

Gap Junctions
Insulin
Insulin-Secreting Cells*
Pancreas*

Substances

Insulin