Tissue-specific early and late activated lymphocytes immunophenotype in chronic rhinosinusitis with nasal polyps

Abstract

T-cell activation in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) is enriched by late cytotoxic T cells. The proportion of early and intermediate activated cytotoxic T cells decreases in nasal polyps of patients with CRSwNP. Our results identify late activated cytotoxic T cells as potential biomarkers or therapeutic targets for patients with CRSwNP.

Keywords: SNOT-22; allergic rhinitis; asthma; biomarker; chronic disease; chronic rhinosinusitis; quality of life.