Improvement in joint inflammation is accompanied by reduction in arterial inflammation: Tocilizumab in rheumatoid arthritis

Hadil Zureigat; Giovanni Civieri; Shady Abohashem; Michael T Osborne; Daniel H Solomon; Jon T Giles; Joan Bathon; Elena Massarotti; Sebastian Unizony; Ahmed Tawakol

doi:10.1016/j.nuclcard.2024.101813

Improvement in joint inflammation is accompanied by reduction in arterial inflammation: Tocilizumab in rheumatoid arthritis

J Nucl Cardiol. 2024 Mar:33:101813. doi: 10.1016/j.nuclcard.2024.101813. Epub 2024 Jan 22.

Authors

Affiliations

¹ Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Cleveland Clinic, Cleveland, OH, USA.
² Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.
³ Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁴ Division of Rheumatology, Inflammation, and Immunity Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA.
⁵ Division of Rheumatology, Columbia University Irving Medical Center, New York, NY, USA.
⁶ Rheumatology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
⁷ Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: atawakol@mgh.harvard.edu.

PMID: 38266667
PMCID: PMC10939751 (available on 2025-03-01)
DOI: 10.1016/j.nuclcard.2024.101813

Abstract

Study design and main results of the study.

Abbreviations: ¹⁸F-FDG-PET-MR^: ¹⁸F-fluorodeoxyglucose-positron emission tomographymagnetic resonance; L: left; R: right; RA: rheumatoid arthritis; SUV: standardized uptake value; TBR: target-to-background ratio.

Keywords: Hybrid imaging; Inflammation; PET; Vascular imaging.

MeSH terms

Antibodies, Monoclonal, Humanized / therapeutic use
Arteritis*
Arthritis, Rheumatoid* / diagnostic imaging
Arthritis, Rheumatoid* / drug therapy
Humans
Inflammation
Treatment Outcome

Substances

tocilizumab
Antibodies, Monoclonal, Humanized

Grants and funding

K23 HL151909/HL/NHLBI NIH HHS/United States