12th Tuscany Retreat on Cancer Research and Apoptosis: Genetic profiling, resistance mechanisms and novel treatment concepts in cancer and neurodegeneration

Cristiano Ramos; Debora Bonasera; Julia Saggau; Julijan Kabiljo; Peter Lin; Sofya Tishina; María G Rincón

doi:10.1016/j.bbamcr.2024.119677

12th Tuscany Retreat on Cancer Research and Apoptosis: Genetic profiling, resistance mechanisms and novel treatment concepts in cancer and neurodegeneration

Biochim Biophys Acta Mol Cell Res. 2024 Mar;1871(3):119677. doi: 10.1016/j.bbamcr.2024.119677. Epub 2024 Jan 23.

Authors

Cristiano Ramos¹, Debora Bonasera², Julia Saggau², Julijan Kabiljo³, Peter Lin⁴, Sofya Tishina⁵, María G Rincón⁶

Affiliations

¹ Department of General Surgery, Division of Visceral Surgery, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
² Cell death, inflammation and immunity laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, 50931 Cologne, Germany; Genetic instability, cell death and inflammation laboratory, Institute of Biochemistry I, Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, Germany.
³ Department of General Surgery, Division of Visceral Surgery, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria; Comprehensive Cancer Center Vienna, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria; Ludwig Boltzmann Institute Applied Diagnostics, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
⁴ Department of Medical Biophysics, University of Toronto, Toronto, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.
⁵ Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging- Associated Diseases (CECAD), Medical Faculty, University of Cologne, Joseph- Stelzmann-Straße 26, 50931 Cologne, Germany.
⁶ Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Stefan Meier Strasse 17, 79104 Freiburg, Germany. Electronic address: gabriela-rincon@mol-med.uni-freiburg.de.

PMID: 38266659
DOI: 10.1016/j.bbamcr.2024.119677

Abstract

The 12th Tuscany Retreat on Cancer Research and Apoptosis was held on August 19-26, 2023. The biennial retreat aims to bring together scientists who advance research in cancer, cell death, and neurodegenerative diseases. Topics covered ranged from drug resistance in cancer to insights into novel molecular cell signaling mechanisms and targets, all related to the pathways and molecules that regulate programmed cell death and the diseases that result from the dysregulation of programmed cell death. In this meeting review, we summarize the content of the most recent retreat.

Keywords: Apoptosis; BCL-2 family; Cancer; Inflammation; Neurodegeneration.

Publication types

Review

MeSH terms

Apoptosis / genetics
Cell Death
Drug Resistance, Neoplasm / genetics
Humans
Neoplasms* / drug therapy
Neoplasms* / genetics
Signal Transduction