The biological functions and related signaling pathways of SPON2

Jingrun Zhang; Ge Liu; Yuchen Liu; Pei Yang; Junyuan Xie; Xiaowei Wei

doi:10.3389/fonc.2023.1323744

The biological functions and related signaling pathways of SPON2

Front Oncol. 2024 Jan 9:13:1323744. doi: 10.3389/fonc.2023.1323744. eCollection 2023.

Authors

Jingrun Zhang^{1

2}, Ge Liu², Yuchen Liu¹, Pei Yang³, Junyuan Xie⁴, Xiaowei Wei²

Affiliations

¹ Zhongshan Clinical College, Dalian University, Dalian, China.
² Laboratory of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.
³ Department of Neurology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
⁴ Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Abstract

Spondin-2 (SPON2), also referred to as M-spondin or DIL-1, is a member of the extracellular matrix protein family known as Mindin-F-spondin (FS). SPON2 can be used as a broad-spectrum tumor marker for more than a dozen tumors, mainly prostate cancer. Meanwhile, SPON2 is also a potential biomarker for the diagnosis of certain non-tumor diseases. Additionally, SPON2 plays a pivotal role in regulating tumor metastasis and progression. In normal tissues, SPON2 has a variety of biological functions represented by promoting growth and development and cell proliferation. This paper presents a comprehensive overview of the regulatory mechanisms, diagnostic potential as a broad-spectrum biomarker, diverse biological functions, involvement in various signaling pathways, and clinical applications of SPON2.

Keywords: SPON2; WNT/β-catenin; biological function; biomarker; signaling pathway.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Dalian University Interdisciplinary Projects (DLUXK-2023-QN-014), and the Science & Technological Convenience Foundation of Dalian (No.2020JJ27SN076).