Nanomaterial-induced pyroptosis: a cell type-specific perspective

Zhiyong Wang; Min Wang; Xuan Zeng; Xupeng Yue; Pei Wei

doi:10.3389/fcell.2023.1322305

Nanomaterial-induced pyroptosis: a cell type-specific perspective

Front Cell Dev Biol. 2024 Jan 9:11:1322305. doi: 10.3389/fcell.2023.1322305. eCollection 2023.

Authors

Zhiyong Wang¹, Min Wang², Xuan Zeng³, Xupeng Yue⁴, Pei Wei¹

Affiliations

¹ Department of Immunology, Zhuhai Campus of Zunyi Medical University, Zhuhai, China.
² Department of Pharmaceutics, Zhuhai Campus of Zunyi Medical University, Zhuhai, China.
³ Department of Pharmaceutics, Guangdong Provincial People's Hospital Zhuhai Hospital, Zhuhai, China.
⁴ College of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, China.

Abstract

This review presents the advancements in nanomaterial (NM)-induced pyroptosis in specific types of cells. We elucidate the relevance of pyroptosis and delineate its mechanisms and classifications. We also retrospectively analyze pyroptosis induced by various NMs in a broad spectrum of non-tumorous cellular environments to highlight the multifunctionality of NMs in modulating cell death pathways. We identify key knowledge gaps in current research and propose potential areas for future exploration. This review emphasizes the need to focus on less-studied areas, including the pathways and mechanisms of NM-triggered pyroptosis in non-tumor-specific cell types, the interplay between biological and environmental factors, and the interactions between NMs and cells. This review aims to encourage further investigations into the complex interplay between NMs and pyroptosis, thereby providing a basis for developing safer and more effective nanomedical therapeutic applications.

Keywords: nanomaterials; non-tumor cells; pyroptosis; therapeutic applications; toxicology.

Publication types

Review

Grants and funding

The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Science and Technology Support Program of Guizhou Province [(2020)4Y191], and the Program of Science and Technology Department of GuiZhou Province [(2022) 619].