Global retinoblastoma studies: A review

Clin Exp Ophthalmol. 2024 Apr;52(3):334-354. doi: 10.1111/ceo.14357. Epub 2024 Jan 23.

Abstract

In the current era of global health awareness for retinoblastoma (RB), the challenge that lies ahead of us is providing optimal care for children affected with RB in underdeveloped nations. The understanding of similarities and disparities between various nations across the world aids in achieving comparable outcomes. With dissolving geographic barriers and evolving collaboration, global collaborative studies on RB are becoming increasingly common. They provide real-world, robust evidence on several aspects of RB. This review discusses insights gained from global RB studies regarding the demographics, certain aspects of etiopathogenesis and epidemiology, international travel burden, disparities in clinical presentations based on national income levels, management protocols, pathology, treatment outcomes, and the effect of COVID-19 on RB care across the world. These insights are likely to impact individual practice as well as inform policy reforms.

Keywords: cancer; eye; global studies; multicentric; retinoblastoma.

Publication types

  • Review

MeSH terms

  • Child
  • Humans
  • Retinal Neoplasms* / diagnosis
  • Retinal Neoplasms* / epidemiology
  • Retinal Neoplasms* / therapy
  • Retinoblastoma* / diagnosis
  • Retinoblastoma* / epidemiology
  • Retinoblastoma* / therapy
  • Treatment Outcome