Emerging applications of single-cell profiling in precision medicine of atherosclerosis

Huiling Lin; Ming Zhang; Mi Hu; Yangkai Zhang; WeiWei Jiang; Wanying Tang; Yuxin Ouyang; Liping Jiang; Yali Mi; Zhi Chen; Pingping He; Guojun Zhao; Xinping Ouyang

doi:10.1186/s12967-023-04629-y

Emerging applications of single-cell profiling in precision medicine of atherosclerosis

J Transl Med. 2024 Jan 23;22(1):97. doi: 10.1186/s12967-023-04629-y.

Authors

Huiling Lin^#^{1

2}, Ming Zhang^#³, Mi Hu¹, Yangkai Zhang¹, WeiWei Jiang⁴, Wanying Tang¹, Yuxin Ouyang¹, Liping Jiang⁵, Yali Mi³, Zhi Chen⁶, Pingping He^#⁷, Guojun Zhao^#⁸, Xinping Ouyang^#^{9

10

11

12}

Affiliations

¹ Department of Physiology, Medical College, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, University of South China, Hengyang, 421001, Hunan, China.
² Department of Physiology, School of Medicine, Hunan Normal University, Changsha, 410081, Hunan, China.
³ Affiliated Qingyuan Hospital, Guangzhou Medical University (Qingyuan People's Hospital), Qingyuan, 511518, Guangdong, China.
⁴ Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
⁵ Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁶ College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, China.
⁷ Department of Nursing, School of Medicine, Hunan Normal University, Changsha, 410081, Hunan, China. hpp-612@163.com.
⁸ Affiliated Qingyuan Hospital, Guangzhou Medical University (Qingyuan People's Hospital), Qingyuan, 511518, Guangdong, China. zhaoguojun@gzhmu.edu.cn.
⁹ Department of Physiology, Medical College, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, University of South China, Hengyang, 421001, Hunan, China. y1655@163.com.
¹⁰ Department of Physiology, School of Medicine, Hunan Normal University, Changsha, 410081, Hunan, China. y1655@163.com.
¹¹ The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Medicine, Hunan Normal University, 410081, Hunan, Changsha, China. y1655@163.com.
¹² The Engineering Research Center of Reproduction and Translational Medicine of Hunan Province, School of Medicine, Hunan Normal University, 410081, Hunan, Changsha, China. y1655@163.com.

^# Contributed equally.

Abstract

Atherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at improving efficacy and prolonging survival, atherosclerosis remains largely incurable. In this review, we discuss emerging single-cell sequencing techniques and their novel insights into atherosclerosis. We provide examples of single-cell profiling studies that reveal phenotypic characteristics of atherosclerosis plaques, blood, liver, and the intestinal tract. Additionally, we highlight the potential clinical applications of single-cell analysis and propose that combining this approach with other techniques can facilitate early diagnosis and treatment, leading to more accurate medical interventions.

Keywords: Atherosclerosis; Cellular heterogeneity; Precision medicine; Single-cell sequencing.

Publication types

Review

MeSH terms

Arteries
Atherosclerosis*
Humans
Liver
Plaque, Atherosclerotic*
Precision Medicine

Abstract

Publication types

MeSH terms

Grants and funding