Emerging insights into keratin 7 roles in tumor progression and metastasis of cancers

Abstract

Keratin 7 (KRT7), also known as cytokeratin-7 (CK-7) or K7, constitutes the principal constituent of the intermediate filament cytoskeleton and is primarily expressed in the simple epithelia lining the cavities of the internal organs, glandular ducts, and blood vessels. Various pathological conditions, including cancer, have been linked to the abnormal expression of KRT7. KRT7 overexpression promotes tumor progression and metastasis in different human cancers, although the mechanisms of these processes caused by KRT7 have yet to be established. Studies have indicated that the suppression of KRT7 leads to rapid regression of tumors, highlighting the potential of KRT7 as a novel candidate for therapeutic interventions. This review aims to delineate the various roles played by KRT7 in the progression and metastasis of different human malignancies and to investigate its prognostic significance in cancer treatment. Finally, the differential diagnosis of cancers based on the KRT7 is emphasized.

Keywords: Acetyl-CoA synthetase-2 (ACSS2); Keratin 8 (KRT8); cytokeratin-7 (CK -7); epithelialmesenchymal transition (EMT); keratin-7 (K7); microsatellite instability (MSI); microsatellite stability (MSS); progression-free survival (PFS).