Transplantable Murine Tumors in the Studies of Peptide Antitumor Vaccines

Abstract

Numerous studies have shown that antitumor vaccines based on synthetic peptides are safe and can induce both CD8⁺ and CD4⁺ tumor-specific T cell responses. However, clinical results are still scarce, and such approach to antitumor treatment has not gained a wide implication, yet. Recently, particular advances have been achieved due to tumor sequencing and the search for immunogenic neoantigens caused by mutations. One of the most important issues for peptide vaccines, along with the choice of optimal adjuvants and vaccination regimens, is the search for effective target antigens. Extensive studies of peptide vaccines, including those on murine models, are required to reveal the effective vaccine constructs. The review presents transplantable murine tumors with the detected peptides that showed antitumor efficacy as a vaccine compound.

Keywords: antigens; antitumor vaccines; neoantigens; peptides; transplantable murine tumors.