Tolerogenic dendritic cells in radiation-induced lung injury

Benbo Liu; Yilong Wang; Gencheng Han; Maoxiang Zhu

doi:10.3389/fimmu.2023.1323676

Tolerogenic dendritic cells in radiation-induced lung injury

Front Immunol. 2024 Jan 8:14:1323676. doi: 10.3389/fimmu.2023.1323676. eCollection 2023.

Authors

Benbo Liu¹, Yilong Wang¹, Gencheng Han¹, Maoxiang Zhu¹

Affiliation

¹ Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, China.

Abstract

Radiation-induced lung injury is a common complication associated with radiotherapy. It is characterized by early-stage radiation pneumonia and subsequent radiation pulmonary fibrosis. However, there is currently a lack of effective therapeutic strategies for radiation-induced lung injury. Recent studies have shown that tolerogenic dendritic cells interact with regulatory T cells and/or regulatory B cells to stimulate the production of immunosuppressive molecules, control inflammation, and prevent overimmunity. This highlights a potential new therapeutic activity of tolerogenic dendritic cells in managing radiation-induced lung injury. In this review, we aim to provide a comprehensive overview of tolerogenic dendritic cells in the context of radiation-induced lung injury, which will be valuable for researchers in this field.

Keywords: inflammation; radiation-induced lung injury(RILI); regulatory B cells(Bregs); regulatory T cells(Tregs); tolerogenic dendritic cells(tolDCs).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Dendritic Cells
Humans
Lung Injury* / etiology
Pulmonary Fibrosis*
Radiation Injuries* / therapy
Radiation Pneumonitis* / etiology

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by grants from the National Natural Science Foundation of China (81673095).