Maintaining the stability of noble metals is the key to the long-term stability of supported catalysts. In response to the instability of noble metal species at high temperatures, we developed a synergistic strategy of dual oxide supports. By designing and constructing ceria components with small sizes, we have achieved unity in the ability of catalytic materials to supply oxygen and stabilize metal species. In this study, we prepared Al2O3-CeO2-Pd (AlCePd) catalysts containing trace amounts of Ce through the hydrolysis of cerium acetate, which achieved 100% CO conversion at 160 °C. More importantly, the activity remained at its initial 100% in the long-term durability testing, demonstrating the high stability of AlCePd. In contrast, the CO conversion of the CeO2-Pd (CePd) catalyst decreased from 100% to 54% within 3 h. Through comprehensive studies, we found that this excellent catalytic performance stems from the stabilizing effect of an alumina support and the possible reverse oxygen spillover effect of small-sized ceria components, where small-sized ceria components provide active oxygen for independent Pd species, making it possible for the CO adsorbed on Pd to react with this oxygen species.