Beating Heart Transplantation: How to Do It

Innovations (Phila). 2024 Jan-Feb;19(1):88-91. doi: 10.1177/15569845231220678. Epub 2024 Jan 23.

Abstract

Heart transplantation utilizing deceased after circulatory death (DCD) donors has expanded the donor pool through the use of ex vivo normothermic perfusion. Compared with brain death donation, the conventional method of performing DCD heart transplantation includes an additional period of warm and cold ischemia. We have developed a beating heart implantation technique that obliviates the need for a second cardioplegic arrest and the associated reperfusion injury. We hypothesize this reproducible method may improve short-term and long-term outcomes to mirror results seen in brain death donors and provide details on how to perform beating heart transplantation.

Keywords: ex vivo organ perfusion; heart transplantation; organ preservation.

MeSH terms

  • Brain Death*
  • Heart Transplantation* / methods
  • Humans
  • Perfusion / methods
  • Tissue Donors