Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized study

Yinzhen Zhang; Yanpeng Wang; Ji Xu; Zhengyan Wang; Wenhai Zhao; Changwei Zhao

doi:10.3389/fmed.2023.1324449

Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized study

Front Med (Lausanne). 2024 Jan 5:10:1324449. doi: 10.3389/fmed.2023.1324449. eCollection 2023.

Authors

Yinzhen Zhang^#¹, Yanpeng Wang^#¹, Ji Xu², Zhengyan Wang¹, Wenhai Zhao³, Changwei Zhao³

Affiliations

¹ Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.
² Department of Spinal Orthopedics, Weifang Hospital of Traditional Chinese Medicine, Weifang, China.
³ Department of Orthopedics, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.

^# Contributed equally.

Abstract

Background: The relationship between visceral adipose tissue and osteoarthritis is not clear. The purpose of our study was to explore the relationship between visceral adipose tissue and osteoarthritis.

Methods: We used a two-sample Mendelian randomization method to select single-nucleotide polymorphisms (SNPs) significantly associated with visceral adipose tissue as instrumental variables to explore the relationship between visceral adipose tissue and all osteoarthritis, hand osteoarthritis, hip osteoarthritis, knee osteoarthritis, and spine osteoarthritis. The reliability of the results was tested using sensitivity analysis.

Results: Our findings indicated that visceral adipose tissue was associated with all osteoarthritis, hip osteoarthritis, knee osteoarthritis, and spine osteoarthritis (all osteoarthritis: OR = 1.399, 95% CI: 1.335-1.467, p = 7.95e-44; hip osteoarthritis: OR = 1.399, 95% CI: 1.284-1.524, p = 1.41e-14; knee osteoarthritis: OR = 1.794, 95% CI: 1.662-1.937, p = 1.33e-50; and spine osteoarthritis: OR = 1.445, 95% CI: 1.314-1.589, p = 2.89e-14). Sensitivity analysis demonstrated the reliability of these results.

Conclusion: Our study suggests that genetically predicted visceral adipose tissue is associated with osteoarthritis. Reducing the accumulation of visceral adipose tissue could potentially have an impact on the incidence of osteoarthritis.

Keywords: Mendelian randomization; obesity; osteoarthritis; two-sample MR; visceral adipose tissue.

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the 2021 project of the Jilin Science and Technology Development Plan (20210303004SF) and the Natural Science Foundation of Jilin Province (YDZJ202201ZYTS216).