New insights into metabolic dysfunction-associated steatotic liver disease and oxidative balance score

Lei Peng; Lurong Li; Jiahao Liu; Yuanyuan Li

doi:10.3389/fnut.2023.1320238

New insights into metabolic dysfunction-associated steatotic liver disease and oxidative balance score

Front Nutr. 2024 Jan 5:10:1320238. doi: 10.3389/fnut.2023.1320238. eCollection 2023.

Authors

Lei Peng^#¹, Lurong Li^#¹, Jiahao Liu^#¹, Yuanyuan Li^#²

Affiliations

¹ Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
² Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing, China.

^# Contributed equally.

Abstract

Background: The relationship between oxidative stress and metabolic dysfunction-associated steatotic liver disease (MASLD) has not been studied, which remains inadequately recognized. This is a cross-sectional study in a US adult population to explore the relationship between MASLD and oxidative balance scores (OBS), which containing integrating dietary nutrition and lifestyle factors.

Methods: We analyzed data from National Health and Nutrition Examination Survey during 2017-2018. Multivariate logistic regression, restricted cubic spline curve (RCS) and subgroup analysis were used to investigate the association between OBS and MASLD. Cox regression analysis was utilized to assess the association between OBS and all-cause mortality among individuals.

Results: The multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) for the highest quartile of OBS (Q4) was 0.30 (0.12, 0.77) (p = 0.012) compared to the lowest quartile of OBS (Q1). The RCS regression and subgroup analysis indicated an inverted relationship between OBS and the development of MASLD. The OBS Q4 group (HR: 0.15, 95% CI: 0.03-0.87; p = 0.035) exhibited a lower risk of all-cause death than the Q1 group.

Conclusion: OBS is statistically significantly and negatively correlated with the risk of MASLD and all-cause mortality in US adults. More prospective investigations are required to substantiate our findings.

Keywords: NHANES; metabolic dysfunction-associated steatotic liver disease (MASLD); mortality; nutrition; oxidative balance score (OBS).

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Nature Science Foundation of China (Nos. 82100595 and 82100712) and the Natural Science Foundation of Jiangsu Province (No. BK20210958).