Breakthrough of solid tumor treatment: CAR-NK immunotherapy

Wenkang Wang; Yang Liu; Zhen He; Lifeng Li; Senbo Liu; Mingqiang Jiang; Bing Zhao; Meng Deng; Wendong Wang; Xuefang Mi; Zhenqiang Sun; Xin Ge

doi:10.1038/s41420-024-01815-9

Breakthrough of solid tumor treatment: CAR-NK immunotherapy

Cell Death Discov. 2024 Jan 20;10(1):40. doi: 10.1038/s41420-024-01815-9.

Authors

Wenkang Wang¹, Yang Liu², Zhen He³, Lifeng Li⁴, Senbo Liu⁵, Mingqiang Jiang⁶, Bing Zhao⁶, Meng Deng⁶, Wendong Wang⁶, Xuefang Mi⁶, Zhenqiang Sun⁷, Xin Ge⁸

Affiliations

¹ Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. fccwangwk@zzu.edu.cn.
² Department of Radiotherapy, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
³ Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
⁴ Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁵ Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁶ Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁷ Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. fccsunzq@zzu.edu.cn.
⁸ Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. gexin1981@126.com.

Abstract

As the latest and most anticipated method of tumor immunotherapy, CAR-NK therapy has received increasing attention in recent years, and its safety and high efficiency have irreplaceable advantages over CAR-T. Current research focuses on the application of CAR-NK in hematological tumors, while there are fewer studies on solid tumor. This article reviews the process of constructing CAR-NK, the effects of hypoxia and metabolic factors, NK cell surface receptors, cytokines, and exosomes on the efficacy of CAR-NK in solid tumor, and the role of CAR-NK in various solid tumor. The mechanism of action and the research status of the potential of CAR-NK in the treatment of solid tumor in clinical practice, and put forward the advantages, limitations and future problems of CAR-NK in the treatment of solid tumor.

Publication types

Review