The uncharted territory of NAD+-capped RNA

Quan Ma; Jianzhao Liu; Hao Hu; Zisheng Luo

doi:10.1016/j.tcb.2023.12.005

The uncharted territory of NAD⁺-capped RNA

Trends Cell Biol. 2024 May;34(5):355-359. doi: 10.1016/j.tcb.2023.12.005. Epub 2024 Jan 18.

Authors

Quan Ma¹, Jianzhao Liu², Hao Hu³, Zisheng Luo⁴

Affiliations

¹ Zhejiang University, College of Biosystems Engineering and Food Science, Hangzhou 310058, China.
² MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China.
³ Department of Botany and Plant Sciences, Institute of Integrative Genome Biology, University of California, Riverside, CA 92521, USA. Electronic address: haohu@ucr.edu.
⁴ Zhejiang University, College of Biosystems Engineering and Food Science, Hangzhou 310058, China; Ningbo Innovation Center, Zhejiang University, Ningbo 315100, China. Electronic address: luozisheng@zju.edu.cn.

PMID: 38242774
DOI: 10.1016/j.tcb.2023.12.005

Abstract

The critical redox cofactor NAD⁺ was recently reported to serve as an RNA cap in both eukaryotes and prokaryotes. However, its reversible regulation and biological functions remain unclear. Here, we provide insights into its discovery, capping and decapping mechanisms, for further discovery of their potential functional implications.

Keywords: NAD(+)-capped RNA; NAD–RNA detection and profiling; RNAylation; capping and decapping; click conjugation; molecular and biological function.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
NAD* / metabolism
RNA Caps* / metabolism

Substances

NAD
RNA Caps