Update on novel synthetic approaches towards the construction of carbazole nuclei: a review

RSC Adv. 2024 Jan 18;14(5):2929-2946. doi: 10.1039/d3ra07270c. eCollection 2024 Jan 17.

Abstract

The carbazole scaffold is a significant entity in organic compounds due to its variety of biological and synthetic applications. Traditionally, carbazole skeletons have been synthesized either via the Grabe-Ullman method, Clemo-Perkin method or Tauber method. With the passage of time, these methods have been modified and explored to accomplish the synthesis of target compounds. These methods include hydroarylations, C-H activations, annulations and cyclization reactions mediated by a variety of catalysts to construct carbazole-based compounds. This brief review article intends to provide recent updates on important methodological developments reported for the synthesis of carbazole nuclei covering 2019-2023.

Publication types

  • Review