Functional connectivity via the dorsolateral prefrontal cortex in the late phase of rest periods predicts offline learning

Abstract

The relationship between offline learning gains and functional connectivity (FC) has been investigated in several studies. They have focused on average motor task performance and resting-state FC across subjects. Generally, individual differences are seen in both offline learning gain and neurophysiological profiles in resting-state FC. However, few studies have focused on the relationship between individual differences in offline learning gain and temporal characteristics of resting-state FC. The present study aimed to clarify this relationship between the two profiles. Thirty-four healthy right-handed participants performed a force-controlled motor task. Electroencephalography was performed during the 15-minute wakeful rest period between tasks. The results revealed a significant correlation between offline learning gain and FC between the contralateral dorsolateral prefrontal cortex (DLPFC) and contralateral primary motor cortex (M1), and ipsilateral primary somatosensory cortex (S1) during late phase of the rest interval. These results are consistent with the findings of previous studies showing the FC between M1, which is necessary for awake offline learning, and DLPFC, which is related to motor control. Additionally, sensory feedback related to force control may be caused by the interaction between contralateral DLPFC and ipsilateral S1. Our study shed light on the temporal profiles of resting-state FC associated with individual differences in offline learning.

Keywords: Dorsolateral prefrontal cortex; Functional connectivity; Implicit motor learning; Individual difference; Offline learning; Primary motor cortex.