Straightforward Access to Free β2,3,3-Amino Acids through One Pot C-H Activation/C-C Cleavage

Abstract

The first synthesis of unnatural β^2,3,3-amino acids with a spirocyclic backbone by one-pot protocol has been presented. This reaction features wide functional group tolerance and feasibility of post-functionalization of natural products and biologically important molecules. Novel dipeptide and tripeptide structures were assembled using this newly developed β^2,3,3-amino acid in high efficiency. The combination of C-H activation and C-C cleavage for the synthesis of β-amino acids would trigger more promising synthetic routes for this compound.

Keywords: C−C Cleavage; C−H Activation; One Pot Reaction; β-Amino Acids.