Mental Workload in Neuropsychology: An Example With the NASA-TLX in Adults With HIV

David J Hardy; Charles H Hinkin

doi:10.3389/fnrgo.2022.881653

Mental Workload in Neuropsychology: An Example With the NASA-TLX in Adults With HIV

Front Neuroergon. 2022 May 11:3:881653. doi: 10.3389/fnrgo.2022.881653. eCollection 2022.

Authors

David J Hardy^{1

2}, Charles H Hinkin^{2

3}

Affiliations

¹ Department of Psychology, Loyola Marymount University, Los Angeles, CA, United States.
² Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
³ VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States.

Abstract

A preliminary set of analyses are presented, where workload was examined in 32 adults infected with the human immunodeficiency virus (HIV). Like the current COVID-19 pandemic (caused by the SARS-CoV-2 virus), HIV can produce a wide variety of symptoms, including various levels of cognitive dysfunction. In fact, a recent meta-analysis estimates that of the 39 million adults infected globally with HIV, 42.6% exhibit some form of HIV-associated neurocognitive disorder. A common cognitive symptom in HIV is decline in attention and executive functioning. Though typically examined by clinicians with less precise traditional paper-and-pencil neuropsychological tests, we examined this aspect of cognitive functioning using a more psychometrically sophisticated task as we had HIV-positive adults perform a computerized tracking task in single, dual, and tri-task conditions via the Multi-Attribute Task (MAT) Battery. Also assessed was mental workload, with the NASA-Task Load Index (NASA-TLX), rarely used in neuropsychology but a standard tool in human factors and neuroergonomics research. As expected, tracking performance declined with task condition difficulty (p < 0.001). Although no direct statistical comparisons were made, MAT performance here appeared worse than the MAT performance of various other groups reported in the research literature and in our laboratory. Ratings of workload also tended to increase as a function of task condition difficulty (p < 0.001). Plotting MAT tracking performance against the Mental Demand subscale scores, large individual differences in this aspect of workload were evident in both optimal and sub-optimal tracking performance. To examine likely variables with a potential impact on Mental Demand, a variety of variables (nadir CD4 count, viral load, depression symptoms, diagnosis of AIDS, presence of opportunistic infection, general cognitive status, etc.) were examined in relation to the Mental Demand scale, with age showing a significant association (r = 0.41, p = 0.022) and a diagnosis of AIDS showing trend associations (ps ≥ 0.066). Findings suggesting a deficit in metacognition or insight are also discussed. It is argued that assessment of workload (and its various aspects or components) can provide valuable additional information in neuropsychology.

Keywords: HIV; Multi-Attribute Task Battery; NASA-TLX; mental workload; neuroergonomics; neuropsychology; workload.