Chronic subthreshold cortical stimulation: A promising therapy for motor cortex seizures

Sebastien Heyndrickx; Simon Lamquet; Joyce Oerlemans; Kristl Vonck; Paul Boon; Dirk Van Roost; Alfred Meurs

doi:10.1016/j.ebr.2023.100638

Chronic subthreshold cortical stimulation: A promising therapy for motor cortex seizures

Epilepsy Behav Rep. 2023 Dec 20:25:100638. doi: 10.1016/j.ebr.2023.100638. eCollection 2024.

Authors

Sebastien Heyndrickx¹, Simon Lamquet¹, Joyce Oerlemans¹, Kristl Vonck¹, Paul Boon¹, Dirk Van Roost², Alfred Meurs¹

Affiliations

¹ Department of Neurology, Ghent University Hospital, Ghent, Belgium.
² Department of Neurosurgery, Ghent University Hospital, Ghent, Belgium.

Abstract

Chronic subthreshold cortical stimulation (CSCS) is a form of neurostimulation consisting of continuous or cyclic, open-loop, subthreshold electrical stimulation of a well-defined epileptogenic zone (EZ). CSCS has seen limited clinical use but could be a safe and effective long-term treatment of focal drug resistant epilepsy, in particular when the EZ is located in the motor cortex. We present a case of a 49-year-old woman suffering from debilitating focal motor seizures. Treatment with CSCS resulted in significant clinical improvement, enabling her to walk unaided for the first time in years.

Keywords: Chronic subthreshold cortical stimulation; Drug resistant epilepsy; Neurostimulation.

Publication types

Case Reports