Hunting for the vulnerability in chondrosarcoma by tracing metabolic and genetic links

Yi-Jun Kim; Hyun Guy Kang; Jin-Hong Kim

doi:10.1016/j.xcrm.2023.101385

Hunting for the vulnerability in chondrosarcoma by tracing metabolic and genetic links

Cell Rep Med. 2024 Jan 16;5(1):101385. doi: 10.1016/j.xcrm.2023.101385.

Authors

Yi-Jun Kim¹, Hyun Guy Kang², Jin-Hong Kim³

Affiliations

¹ Department of Environmental Medicine, College of Medicine, Ewha Womans University, Seoul 07804, South Korea; Department of Radiation Oncology, College of Medicine, Ewha Womans University, Seoul 07804, South Korea.
² Orthopaedic Oncology Clinic, Research Institute and Hospital, National Cancer Center, Goyang 10408, South Korea.
³ Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, South Korea; Center for RNA Research, Institute for Basic Science, Seoul 08826, South Korea. Electronic address: jinhkim@snu.ac.kr.

Abstract

In this Backstory, we narrate our journey in establishing a multidisciplinary team for sarcoma research and uncovering vulnerabilities in chondrosarcoma cells associated with their NAD⁺ dependencies for survival.¹ Our findings hold promise for exploitation, yielding a synergistic cytotoxic effect when combined with systemic therapy.

Publication types

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MeSH terms

Antineoplastic Agents* / therapeutic use
Bone Neoplasms* / drug therapy
Bone Neoplasms* / genetics
Chondrosarcoma* / drug therapy
Chondrosarcoma* / genetics
Humans

Substances

Antineoplastic Agents