Advances in the research on myokine-driven regulation of bone metabolism

MingHong Shao; QiYang Wang; QiuNan Lv; YuQiong Zhang; GuoXi Gao; Sheng Lu

doi:10.1016/j.heliyon.2023.e22547

Advances in the research on myokine-driven regulation of bone metabolism

Heliyon. 2023 Nov 20;10(1):e22547. doi: 10.1016/j.heliyon.2023.e22547. eCollection 2024 Jan 15.

Authors

MingHong Shao¹, QiYang Wang¹, QiuNan Lv¹, YuQiong Zhang¹, GuoXi Gao¹, Sheng Lu¹

Affiliation

¹ Department of Orthopedic Surgery, the Key Laboratory of Digital Orthopaedics of Yunnan Provincial, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.

Abstract

The traditional view posits that bones and muscles interact primarily through mechanical coupling. However, recent studies have revealed that myokines, proteins secreted by skeletal muscle cells, play a crucial role in the regulation of bone metabolism. Myokines are widely involved in bone metabolism, influencing bone resorption and formation by interacting with factors related to bone cell secretion or influencing bone metabolic pathways. Here, we review the research progress on the myokine regulation of bone metabolism, discuss the mechanism of myokine regulation of bone metabolism, explore the pathophysiological relationship between sarcopenia and osteoporosis, and provide future perspectives on myokine research, with the aim of identify potential specific diagnostic markers and therapeutic entry points.

Keywords: Bone metabolism; Myokine; Osteoblasts; Osteoclasts; Osteoporosis; Sarcopenia.

Publication types

Review