Resolution of Cardiac Infiltration Following Autologous Stem Cell Transplantation for AL Amyloidosis

Kai Yi Wu; Craig R Butler; Nowell M Fine; Christopher Venner; D Ian Paterson

doi:10.1016/j.jaccas.2023.102142

Resolution of Cardiac Infiltration Following Autologous Stem Cell Transplantation for AL Amyloidosis

JACC Case Rep. 2023 Nov 30;29(1):102142. doi: 10.1016/j.jaccas.2023.102142. eCollection 2024 Jan 3.

Authors

Kai Yi Wu¹, Craig R Butler¹, Nowell M Fine², Christopher Venner³, D Ian Paterson⁴

Affiliations

¹ Mazankowski Alberta Heart Institute, Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada.
² Libin Cardiovascular Institute, Division of Cardiology, University of Calgary, Calgary, Alberta, Canada.
³ BC Cancer Centre for Lymphoid Cancer, University of British Columbia, Vancouver, British Columbia, Canada.
⁴ University of Ottawa Heart Institute, Division of Cardiology, University of Ottawa, Ottawa, Ontario, Canada.

Abstract

A 43-year-old man presented with severe heart failure secondary to high-risk light chain cardiac amyloidosis. He underwent chemotherapy and autologous stem cell transplantation with complete hematologic response. Serial cardiac magnetic resonance imaging post-transplant demonstrated gradual normalization of biventricular function and myocardial T₁, a surrogate measure of disease burden.

Keywords: cardiac amyloidosis; cardiac magnetic resonance imaging; multiple myeloma.

Publication types

Case Reports